The most effective weight-loss medications ever studied, prescribed and supervised by a licensed provider, paired with the labs and coaching that make results last.
Semaglutide and tirzepatide are weekly injectable medications that mimic gut hormones to reduce appetite, slow digestion, and help regulate blood sugar. The result is reduced hunger and food noise, making a sustainable calorie deficit far easier to maintain, which is why they produce far greater weight loss than diet and exercise alone.
Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GLP-1 and GIP receptor agonist, it acts on two appetite-regulating pathways instead of one, which is why it has produced even greater average weight loss in clinical trials.
Both are excellent options. The right one depends on your goals, your health profile, and your provider's recommendation.
| Semaglutide | Tirzepatide | |
|---|---|---|
| Drug class | GLP-1 agonist | Dual GLP-1 / GIP agonist |
| Administration | Weekly injection | Weekly injection |
| Avg. weight loss (trial) | ~15% over 68 weeks | ~21% over 72 weeks |
| Trial reference | STEP 1, NEJM (2021) | SURMOUNT-1, NEJM (2022) |
| Best suited for | Steady, sustainable loss | Higher weight-loss goals |
| Common side effects | Nausea, GI upset (usually temporary) | Nausea, GI upset (usually temporary) |
Figures are trial averages from published studies and do not predict individual results. Eligibility and dosing are determined by your provider.
Average body-weight change in the pivotal clinical trials. Tirzepatide produced greater average loss, though the right medication for you depends on your goals and your provider's guidance.
At Elevra, medical weight loss begins with lab work and a provider consultation to confirm you're a candidate and rule out contraindications. Your provider then prescribes semaglutide or tirzepatide, starts you on a gradual dose-escalation schedule to minimize side effects, and monitors your progress with regular check-ins.
Your provider reviews your health history, current medications, and goals, and screens for conditions where these medications aren't appropriate.
Doses start low and increase over time. This step-up approach helps your body adjust and keeps the most common side effects, usually mild nausea, to a minimum.
Medication does the heavy lifting on appetite; protein, resistance training, and habit support protect your muscle and make the results stick. Your provider helps you build the full picture.
Book a consultation with a licensed Elevra provider in Wentzville and find out which option fits you.
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